Toxicology & Safety Pharmacology
Toxicology & Safety Pharmacology

Toxicology & Safety Pharmacology

InSymbiosis is able to provide GLP compliant toxicology and safety pharmacology services through our partnership network which includes a number of well-respected preclinical CRO’s. This InSymbiosis service includes the management and monitoring of these important studies and, in addition, InSymbiosis is able to offer significant discounts on the overall study cost via utilization of our unique business model.

The key GLP toxicology and safety pharmacology services that InSymbiosis offers are as follows:

General Toxicology

  • Oral, intravenous, intraperitoneal, intramuscular, intravenous infusion, subcutaneous and dermal routes of administration
  • Acute, subchronic, chronic, and carcinogenicity studies
  • Multiple species

Infusion Studies

  • Intravenous and subcutaneous infusion (bolus, intermittent and continuous)
  • Multiple species
  • Validated studies durations of up to 12 months

Inhalation Studies

  • Specialized inhalation methodologies
  • Acute, subchronic, chronic and carcinogenicity studies
  • Multiple species

Genetic Toxicology

  • In vitro bacterial reverse mutation test
  • In vitro mammalian cytogenetic test
  • In vitro mammalian erythrocyte micronucleus assay
  • In vitro mouse lymphoma TK assay

Safety Pharmacology

  • Central nervous system (CNS) studies in rodents and non-rodents (Functional Observational Battery or Modified Irwin Screen)
  • Respiratory evaluations in rodents and non-rodents
  • Cardiovascular studies in conscious, unrestrained naïve or non-naïve animals

Immunotoxicology


Reproductive and Developmental Toxicology


Please see our Regulatory Toxicology & Safety Pharmacology brochure for more details or Contact Us.